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- Region :China/Zhejiang
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- Details for Colistin Sulphate
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Colistin Sulphate 1264-72-8
Category : Pharmaceuticals and Biochemicals/Antibiotic and antimicrobial agents
CAS NO : 1264-72-8 EC NO : 215-034-3 MF : C52H98N16O13 MW : 1155.4339 Specification : EP / CP Packing : 25kg drum Product description : Colistin Sulphate
Colistin (Polymyxin E) is polymyxin antibiotic isolated from culture fluid of Bacillus polymyxa var colistinus bacteria in soil. Colistin is effective against most Gram-negative bacilli such as E-coil, Serpulina Hyodysenteriae, Salmonella Pullorum and also effective on Pseudomonas aeruginosa.
[Molecular Formula] 2(C52H98N16O13) · 5(H2SO4)
[Molecular Weight] 2801.27
[Specifications for EP7]
Test Items
Specifications
Appearance
White or almost white, hygroscopic powder
Specific Rotation
-63º to -73º
Identification
Positive
pH
4.0 to 6.0
Loss on Drying
3.5% max
Sulphate (Dried Basis)
16.0 to 18.0 %
Sulphated Ash
1.0% max
Total Impurities
23.0% max
Assay HPLC (Dried Basis)
Sum of E1,E2,E1-I,E1-7MOA,E3
77.0% min
Potency (Dried Basis)
19,000 IU/mg min
[Characteristic]
1) Improve growth performance and conversion rate of livestock & poultry;
2) Inhibit Gram-negative bacteria at growth duration or dormancy state;
3) Prevent bacterial diarrhea & synergistic effects with other antibiotics;
4) No cross tolerance with broad range of antibacterial agent;
5) Little absorbed by intestine and stomach, no residue.
[Recommended dosage] g/ton of complete feed
Target Animals
Colistin Sulphate
Withdrawal Period
Swine
<2 months
2(60MU) – 20(600MU)
7 Days
2-4 months
2(60MU) – 40(1,200MU)
Poultry
< 70 days
2(60MU) – 20(600MU)
Cattle
< 3 months
5(150MU) – 40(1,200MU)
Note: 1ug of Colistin is equivalent to 30 units of Colistin; MU = Million Unit
[Precaution]
1) May cause damage in kidney function by overdosing;
2) Prohibited to use during laying period.
[Storage] It should be kept cool and dry in well-closed original package.
[Package] 25kg Drum net each
[Shelf Life] Two Years
Uses : Antibiotic for Animal Use Synonyms : Colistin Sulphate;n-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide sulfate (1:1);N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-5-methylheptanamide;belcomycin; Molecular Structure : 
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Colistin Sulphate